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Founded by Julius Caesar and famous as the “cradle of the Italian Renaissance,” this is an art lover’s paradise. Here, you will find the world’s first modern public gallery in the Uffizi Palace, housing Italy’s most important collection of paintings. Michelangelo’s “David,” so definitively carved that the stone seems to breathe with life, is in the Accademia Gallery. The Duomo, a cathedral begun in 1296, is adorned with magnificent frescoes, but you will find treasures hiding in every corner of this art mecca.